This Biomedical Technology Resource Center, the Case Western Reserve University Center
for Multimodal Evaluation of Engineered Cartilage, is a platform for multidisciplinary
Collaborative and Service Interactions and a broadly accessible resource for developing, testing,
validating, and disseminating new methods of evaluating tissue engineered products.
The purpose of the Center is to provide, in one location, all the technology and expertise needed
to comprehensively evaluate engineered cartilage from the cell and molecular biology, biomechanical,
and biotransport aspects.
The focus is on cartilage, but the technology we develop at the Center will be versatile
and applicable to other tissue types as the concept of multimodal evaluation is fundamental to all
types of tissue constructs. When implanted, an engineered tissue will ultimately have to take over
all the essential functions of its target tissue. Failure can occur in many modes, and multiple minor
deficiencies can have a cumulative effect. This has led us to conclude that robust and validated tools
for continuous monitoring and assessment of the entire tissue engineering process, and of its
end-product, are going to become essential. We realize that monitoring and assessment tools cannot
focus on just one aspect of the TE process, but must address the biological, biochemical and
biomechanical aspects of the process. Such tools will guide the research and development of new TE strategies.
Members of the CCMEEC team have collaborated for decades on cartilage tissue engineering and
the level of experience, expertise, and technology related to cartilage tissue engineering
available at this center is unmatched.